Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.68 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.68 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.68 |
| ▸ | GAK | O14976 | 3/20 | 0.59 |
| ▸ | FBP1 | P09467 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | RAF1 | P04049 | 5/20 | 0.58 |
| ▸ | BRAF | P15056 | 5/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.55 |
| ▸ | BUB1 | O43683 | 2/20 | 0.55 |
| ▸ | STK10 | O94804 | 2/20 | 0.55 |
| ▸ | MAP3K1 | Q13233 | 2/20 | 0.55 |
| ▸ | PIP4K2C | Q8TBX8 | 2/20 | 0.55 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.55 |
| ▸ | CARS1 | P49589 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | PLK4 | O00444 | 1/20 | 0.54 |
| ▸ | CIT | O14578 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7976867 | 0.91 | EGFR (0.70) | EGFRERBB2ERBB4GAKFBP1 | |
| SCHEMBL1507524 | 0.91 | EGFR (0.74) | EGFRERBB2ERBB4GAKFBP1 | |
| SCHEMBL7978774 | 0.89 | EGFR (0.71) | EGFRERBB2ERBB4GAKFBP1 | |
| SCHEMBL7982823 | 0.87 | EGFR (0.68) | EGFRERBB2ERBB4GAKFBP1 | |
| SCHEMBL15051921 | 0.86 | BRAF (0.72) | EGFRERBB2ERBB4GAKFBP1 | |
| SCHEMBL7978611 | 0.86 | EGFR (0.64) | EGFRERBB2ERBB4GAKFBP1 | |
| SCHEMBL1507632 | 0.86 | EGFR (0.60) | EGFRERBB2ERBB4GAKFBP1 | |
| SCHEMBL4787908 | 0.86 | EGFR (0.82) | EGFRERBB2MAPTRAF1BRAF | |
| SCHEMBL7966785 | 0.84 | CYP1A2 (0.72) | EGFRERBB2ERBB4GAKFBP1 | |
| SCHEMBL27756978 | 0.84 | EGFR (0.67) | EGFRERBB2ERBB4GAKFBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6225318-B1 | 4-aminoquinazolone derivatives | PFIZER INC | 2001-05-01 | — | — | US | disclosed |
| EP-0837063-A1 | 4-Aminoquinazoline derivatives | PFIZER INC. (US) | 1998-04-22 | — | — | EP | disclosed |