Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.70 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.70 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.70 |
| ▸ | BRAF | P15056 | 6/20 | 0.69 |
| ▸ | RAF1 | P04049 | 6/20 | 0.69 |
| ▸ | GAK | O14976 | 3/20 | 0.61 |
| ▸ | FBP1 | P09467 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 5/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | USP2 | O75604 | 3/20 | 0.60 |
| ▸ | TSHR | P16473 | 3/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7982859 | 0.91 | EGFR (0.68) | EGFRERBB2ERBB4BRAFRAF1 | |
| SCHEMBL7978774 | 0.91 | EGFR (0.71) | EGFRERBB2ERBB4BRAFRAF1 | |
| SCHEMBL7982823 | 0.89 | EGFR (0.68) | EGFRERBB2ERBB4BRAFRAF1 | |
| SCHEMBL15051921 | 0.88 | BRAF (0.72) | EGFRERBB2ERBB4BRAFRAF1 | |
| SCHEMBL7966785 | 0.88 | CYP1A2 (0.72) | EGFRERBB2ERBB4BRAFRAF1 | |
| SCHEMBL7978611 | 0.88 | EGFR (0.64) | EGFRERBB2ERBB4BRAFRAF1 | |
| SCHEMBL7982836 | 0.86 | EGFR (0.63) | EGFRERBB2ERBB4BRAFRAF1 | |
| SCHEMBL27756978 | 0.85 | EGFR (0.67) | EGFRERBB2ERBB4BRAFRAF1 | |
| SCHEMBL29894409 | 0.85 | ABCG2 (0.76) | EGFRERBB2GAKFBP1ALDH1A1 | |
| SCHEMBL183355 | 0.85 | ABCG2 (0.76) | EGFRERBB2GAKFBP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6225318-B1 | 4-aminoquinazolone derivatives | PFIZER INC | 2001-05-01 | — | — | US | disclosed |
| EP-0837063-A1 | 4-Aminoquinazoline derivatives | PFIZER INC. (US) | 1998-04-22 | — | — | EP | disclosed |