Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.54 |
| ▸ | FLT1 | P17948 | 1/20 | 0.54 |
| ▸ | FLT4 | P35916 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | USP1 | O94782 | 1/20 | 0.41 |
| ▸ | USP8 | P40818 | 1/20 | 0.41 |
| ▸ | OTUB1 | Q96FW1 | 1/20 | 0.41 |
| ▸ | USP36 | Q9P275 | 1/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7983232 | 0.88 | KDR (0.57) | KDRFLT1FLT4ALOX15ALDH1A1 | |
| SCHEMBL7979621 | 0.85 | KDR (0.50) | KDRFLT1FLT4ALOX15ALDH1A1 | |
| SCHEMBL7982616 | 0.85 | KDR (0.56) | KDRFLT1FLT4ALOX15RAB9A | |
| SCHEMBL7980821 | 0.84 | KDR (0.54) | KDRFLT1FLT4ALOX15MAPT | |
| SCHEMBL7983601 | 0.84 | KDR (0.53) | KDRFLT1FLT4ALOX15MAPT | |
| SCHEMBL7981125 | 0.82 | KDR (0.55) | KDRFLT1FLT4ALOX15ALDH1A1 | |
| SCHEMBL7739016 | 0.82 | KDR (0.56) | KDRFLT1FLT4ALOX15ALDH1A1 | |
| SCHEMBL7746582 | 0.81 | KDR (0.62) | KDRFLT1FLT4ALOX15ALDH1A1 | |
| SCHEMBL7739014 | 0.79 | KDR (0.63) | KDRFLT1FLT4ALDH1A1KDM4E | |
| SCHEMBL7983597 | 0.76 | KDR (0.65) | KDRFLT1FLT4RAB9ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6228871-B1 | THIAZOLE OR OXAZOLE DERIVATIVE TYROSINE KINASE INHIBITORS; ANTICARCINOGENIC AGENTS; AUTOIMMUNE DISEASES; DIABETIC RETINOPATHY | MERCK & CO., INC. | 2001-05-08 | — | — | US | claimed |