Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.56 |
| ▸ | FLT1 | P17948 | 1/20 | 0.56 |
| ▸ | FLT4 | P35916 | 1/20 | 0.56 |
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.43 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.43 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | UTRN | P46939 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7980265 | 0.89 | SIRT2 (0.52) | KDRFLT1FLT4SIRT2CYP19A1 | |
| SCHEMBL7979621 | 0.88 | KDR (0.50) | KDRFLT1FLT4CCNE2CCNE1 | |
| SCHEMBL7969453 | 0.87 | HPGD (0.46) | KDRFLT1FLT4SIRT2CYP19A1 | |
| SCHEMBL7980821 | 0.87 | KDR (0.54) | KDRFLT1FLT4CYP19A1CCNE2 | |
| SCHEMBL7983601 | 0.87 | KDR (0.53) | KDRFLT1FLT4CCNE2CCNE1 | |
| SCHEMBL7983236 | 0.85 | KDR (0.54) | KDRFLT1FLT4CCNE2CCNE1 | |
| SCHEMBL7739014 | 0.84 | KDR (0.63) | KDRFLT1FLT4CYP11B1CYP11B2 | |
| SCHEMBL7979692 | 0.84 | KDR (0.54) | KDRFLT1FLT4ALOX15PIK3CA | |
| SCHEMBL7979899 | 0.83 | KDR (0.52) | KDRFLT1FLT4SIRT2CCNE2 | |
| SCHEMBL7739016 | 0.81 | KDR (0.56) | KDRFLT1FLT4CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6228871-B1 | THIAZOLE OR OXAZOLE DERIVATIVE TYROSINE KINASE INHIBITORS; ANTICARCINOGENIC AGENTS; AUTOIMMUNE DISEASES; DIABETIC RETINOPATHY | MERCK & CO., INC. | 2001-05-08 | — | — | US | claimed |