Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.37 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | TYR | P14679 | 1/20 | 0.33 |
| ▸ | CDC25A | P30304 | 7/20 | 0.33 |
| ▸ | CDC25B | P30305 | 7/20 | 0.33 |
| ▸ | DUSP3 | P51452 | 7/20 | 0.33 |
| ▸ | CDC25C | P30307 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7990674 | 0.93 | KDM4E (0.34) | KDM4ELMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7983529 | 0.78 | KDM4E (0.34) | KDM4ELMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7985408 | 0.78 | KDM4E (0.34) | KDM4ELMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7990754 | 0.74 | PTPN1 (0.40) | KDM4ELMNAMAPTSMN1; SMN2TDP1 | |
| SCHEMBL7988278 | 0.74 | PTPN1 (0.40) | LMNAMAPTCYP2C9HSD17B10TDP1 | |
| SCHEMBL7972906 | 0.70 | KDM4E (0.40) | KDM4ELMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8116635 | 0.68 | CES2 (0.51) | LMNACYP1A2MAPTTDP1CES2 | |
| SCHEMBL8775172 | 0.67 | CES2 (0.54) | LMNACYP1A2MAPTTDP1CES2 | |
| SCHEMBL6934073 | 0.67 | CES2 (0.54) | LMNACYP1A2MAPTTDP1CES2 | |
| SCHEMBL8775369 | 0.67 | CES2 (0.54) | LMNACYP1A2MAPTTDP1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6262073-B1 | INHIBITING THE ACTION OF A PRO-INFLAMMATORY CYTOKINE | OXIS INTERNATIONAL INC. | 2001-07-17 | — | — | US | disclosed |
| US-6136832-A | RACEMIC MIXTURES AND ENANTIOMORPHS | OXIS INTERNATIONAL INC. (US) | 2000-10-24 | — | — | US | disclosed |
| US-6005000-A | 5,5-Disubstituted-3, 4-dihydroxy-2(5H)-furanones and methods of use therefor | OXIS INTERNATIONAL, INC. (US) | 1999-12-21 | — | — | US | disclosed |
| EP-0938482-A1 | 5-SUBSTITUTED AND 5,5-DISUBSTITUTED-3,4-DIHYDROXY-2(5H)-FURANONES AND METHODS OF USE THEREFOR | Oxis International, Inc. (US) | 1999-09-01 | — | — | EP | disclosed |
| WO-1998007714-A1 | 5-SUBSTITUTED AND 5,5-DISUBSTITUTED-3,4-DIHYDROXY-2(5H)-FURANONES AND METHODS OF USE THEREFOR | OXIS INTERNATIONAL, INC. (US) | 1998-02-26 | — | — | WO | disclosed |