Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 5/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | HPGD | P15428 | 4/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6872706 | 0.79 | MAPT (0.38) | MAPTKDM4EGAANPC1ABCB11 | |
| SCHEMBL27476345 | 0.77 | HPGD (0.35) | MAPTKDM4EGAANPC1ABCB11 | |
| SCHEMBL8081216 | 0.76 | CYP2C9 (0.39) | MAPTKDM4EGAANPC1ABCB11 | |
| SCHEMBL27557816 | 0.76 | CYP2C9 (0.36) | MAPTKDM4EGAANPC1ABCB11 | |
| SCHEMBL4773364 | 0.75 | DYRK1A (0.36) | GAAALDH1A1 | |
| Hydrochloric Acid SCHEMBL6865752 | 0.72 | MAPT (0.36) | MAPTKDM4EGAANPC1ABCB11 | |
| SCHEMBL6861334 | 0.71 | MAPT (0.35) | MAPTKDM4EGAANPC1ABCB11 | |
| Hydrochloric Acid SCHEMBL8500365 | 0.70 | MAPT (0.34) | MAPTKDM4EGAANPC1ABCB11 | |
| SCHEMBL8081113 | 0.69 | ALDH1A1 (0.38) | MAPTGAANPC1ABCB11PKM | |
| SCHEMBL27971566 | 0.69 | CYP2C9 (0.40) | MAPTGAANPC1ABCB11PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001034578-A1 | COMPOUNDS WITH ANTI-HELICOBACTER PYLORI ACTIVITY | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | disclosed |