Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 18/20 | 0.56 |
| ▸ | ADRB1 | P08588 | 10/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 9/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7967052 | 0.90 | ADRB2 (0.43) | ADRB2ADRB1ADRB3DRD2ADRA1A | |
| SCHEMBL7967289 | 0.88 | ADRB2 (0.45) | ADRB2ADRB1ADRB3DRD2SLC6A4 | |
| SCHEMBL7979102 | 0.88 | ADRB3 (0.54) | ADRB2ADRB3ADRA1A | |
| SCHEMBL7600305 | 0.88 | ADRB3 (0.54) | ADRB2ADRB3ADRA1A | |
| SCHEMBL7600308 | 0.88 | ADRB3 (0.54) | ADRB2ADRB3ADRA1A | |
| Hydrochloric Acid SCHEMBL7979217 | 0.88 | ADRB3 (0.54) | ADRB2ADRB3ADRA1A | |
| Hydrochloric Acid SCHEMBL7979220 | 0.88 | ADRB3 (0.54) | ADRB2ADRB3ADRA1A | |
| Hydrochloric Acid SCHEMBL7983471 | 0.88 | ADRB3 (0.54) | ADRB2ADRB3ADRA1A | |
| SCHEMBL7977520 | 0.86 | ADRB3 (0.48) | ADRB2ADRB3ADRA1A | |
| SCHEMBL7977666 | 0.86 | ADRB2 (0.39) | ADRB2ADRB1ADRB3DRD2ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6172099-B1 | CARBAZOLE, DIBENZOFURAN, OR DIBENZOTHIOPHENE DERIVATIVES; DIETETICS, ANTIDIABETIC AGENTS; ANTILIPEMICS | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 2001-01-09 | — | — | US | claimed |
| EP-0997458-A1 | NOVEL TRICYCLIC COMPOUNDS HAVING SATURATED RINGS AND MEDICINAL COMPOSITIONS CONTAINING THE SAME | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 2000-05-03 | — | — | EP | claimed |
| US-6172099-B1 | CARBAZOLE, DIBENZOFURAN, OR DIBENZOTHIOPHENE DERIVATIVES; DIETETICS, ANTIDIABETIC AGENTS; ANTILIPEMICS | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 2001-01-09 | — | — | US | disclosed |
| EP-0997458-A1 | NOVEL TRICYCLIC COMPOUNDS HAVING SATURATED RINGS AND MEDICINAL COMPOSITIONS CONTAINING THE SAME | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 2000-05-03 | — | — | EP | disclosed |