Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 2/20 | 0.44 |
| ▸ | GCGR | P47871 | 1/20 | 0.44 |
| ▸ | GAK | O14976 | 1/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.44 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.44 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7980252 | 0.88 | GAK (0.43) | CYP11B2GCGRGAKRIPK2COQ8A | |
| SCHEMBL7980256 | 0.88 | GAK (0.43) | CYP11B2GCGRGAKRIPK2COQ8A | |
| SCHEMBL7983690 | 0.81 | MAPT (0.49) | CYP11B2GCGRMAPTALDH1A1MEN1 | |
| SCHEMBL8854395 | 0.74 | CYP1A1 (0.58) | MAPTALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL828159 | 0.73 | GAK (0.55) | GAKRIPK2COQ8ANLKPDPK1 | |
| SCHEMBL15756387 | 0.72 | MAPT (0.50) | CYP11B2MAPTALDH1A1MEN1KMT2A | |
| Iodide SCHEMBL14236729 | 0.71 | GAK (0.54) | GAKRIPK2COQ8ANLKPDPK1 | |
| Iodide SCHEMBL14236731 | 0.71 | GAK (0.54) | GAKRIPK2COQ8ANLKPDPK1 | |
| SCHEMBL7987213 | 0.71 | MAPT (0.42) | CYP11B2GCGRMAPTALDH1A1MEN1 | |
| SCHEMBL7987215 | 0.71 | MAPT (0.42) | CYP11B2GCGRMAPTALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194439-B1 | ANTICANCER AGENT | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |