Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAK | O14976 | 1/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.43 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.43 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.43 |
| ▸ | GCGR | P47871 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7980252 | 1.00 | GAK (0.43) | GAKRIPK2COQ8ANLKGCGR | |
| SCHEMBL7983642 | 0.88 | CYP11B2 (0.44) | GAKRIPK2COQ8ANLKGCGR | |
| SCHEMBL7987213 | 0.71 | MAPT (0.42) | GCGRCYP11B2ERN1NPC1RAB9A | |
| SCHEMBL7987215 | 0.71 | MAPT (0.42) | GCGRCYP11B2ERN1NPC1RAB9A | |
| SCHEMBL7983690 | 0.71 | MAPT (0.49) | GCGRCYP11B2ERN1NPC1RAB9A | |
| SCHEMBL27369081 | 0.71 | GAK (0.50) | GAKRIPK2COQ8ANLKSYK | |
| SCHEMBL7970053 | 0.70 | LMNA (0.47) | MAPTLMNAHPGDMEN1KMT2A | |
| SCHEMBL7970056 | 0.70 | LMNA (0.47) | MAPTLMNAHPGDMEN1KMT2A | |
| SCHEMBL8854395 | 0.69 | CYP1A1 (0.58) | SMN1; SMN2MAPTLMNAALDH1A1CYP1A2 | |
| SCHEMBL460384 | 0.67 | SYK (0.57) | GAKRIPK2COQ8ANLKSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194439-B1 | ANTICANCER AGENT | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |