SCHEMBL7983868

SCHEMBL7983868

COc1cc([C@@H](CC(=O)O)N(C(C)=O)N2C(=O)N[C@](C)(c3ccc(C(=N)N)cc3)C2=O)ccc1O

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ITGB3 P05106 2/20 0.44
ITGA2B P08514 2/20 0.44
GAA P10253 2/20 0.39
CYP3A4 P08684 2/20 0.39
CYP2C19 P33261 2/20 0.39
CYP2C9 P11712 1/20 0.39
NPC1 O15118 1/20 0.38
PDE4D Q08499 1/20 0.35
BLM P54132 2/20 0.33
NFKB1 P19838 1/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
TSHR P16473 1/20 0.33
F7 P08709 3/20 0.33
KLKB1 P03952 1/20 0.33
PMP22 Q01453 1/20 0.33
F10 P00742 2/20 0.33
F2 P00734 1/20 0.33
PRSS1 P07477 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8492974 0.94 ITGB3 (0.45) ITGB3ITGA2BGAACYP3A4CYP2C19
SCHEMBL7969575 0.94 ITGB3 (0.45) ITGB3ITGA2BGAACYP3A4CYP2C19
SCHEMBL7983484 0.90 ITGB3 (0.46) ITGB3ITGA2BCYP3A4CYP2C19CYP2C9
SCHEMBL7985139 0.87 ITGB3 (0.49) ITGB3ITGA2BCYP3A4CYP2C19CYP2C9
SCHEMBL7446193 0.86 GAA (0.38) GAACYP3A4CYP2C19CYP2C9NPC1
SCHEMBL7981888 0.86 ITGB3 (0.50) ITGB3ITGA2BCYP3A4CYP2C19CYP2C9
Hydrochloric Acid SCHEMBL7986512 0.84 ITGB3 (0.56) ITGB3ITGA2BCYP3A4CYP2C19CYP2C9
Hydrochloric Acid SCHEMBL8488362 0.84 ITGB3 (0.56) ITGB3ITGA2BCYP3A4CYP2C19CYP2C9
Hydrochloric Acid SCHEMBL7969557 0.84 ITGB3 (0.56) ITGB3ITGA2BCYP3A4CYP2C19CYP2C9
Hydrochloric Acid SCHEMBL8489120 0.84 ITGB3 (0.56) ITGB3ITGA2BCYP3A4CYP2C19CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6191282-B1 DERIVATIVES OF 5-MEMBERED NITROGEN CONTAINING HETEROCYCLIC RING IS USED AS ANTICARCINOGENIC AGENT AND ANTICOAGULANT HOECHST MARION ROUSSEL (DE) 2001-02-20 US disclosed
US-5981492-A ADMINISTERED TO THE PATIENT TO INHIBIT THROMBOCYTE AGGREGATION, THE METASTASIZATION OF CARCINOMA CELLS, THE BINDING OF OSTEOCLASTS TO THE BONE SURFACE, OR FOR THE TREATMENT OF THROMBOSES HOECHST AKTIENGESELLSCHAFT (DE) 1999-11-09 US disclosed