Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 3/20 | 0.48 |
| ▸ | HTR1B | P28222 | 3/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | IGF1R | P08069 | 1/20 | 0.48 |
| ▸ | FLT4 | P35916 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.47 |
| ▸ | ADRB3 | P13945 | 12/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7967383 | 0.85 | ALOX15 (0.51) | ADRB3ADRB1ALOX15ADRA1AALDH1A1 | |
| SCHEMBL7977145 | 0.85 | ALOX15 (0.51) | ADRB3ADRB1ALOX15ADRA1AALDH1A1 | |
| SCHEMBL7980850 | 0.85 | ALOX15 (0.51) | ADRB3ADRB1ALOX15ADRA1AALDH1A1 | |
| SCHEMBL7980655 | 0.85 | ADRB3 (0.44) | ADRB3ADRB1ALOX15ADRA1A | |
| SCHEMBL7983526 | 0.82 | ADRB3 (0.49) | ADRB3ADRA1A | |
| SCHEMBL6905931 | 0.79 | ALOX15 (0.54) | ADRB3ADRB1ALOX15ADRA1AALDH1A1 | |
| SCHEMBL6912318 | 0.79 | ALOX15 (0.54) | ADRB3ADRB1ALOX15ADRA1AALDH1A1 | |
| SCHEMBL6912018 | 0.79 | ALOX15 (0.54) | ADRB3ADRB1ALOX15ADRA1AALDH1A1 | |
| SCHEMBL7977543 | 0.79 | ADRB3 (0.46) | ADRB3ADRB1ALOX15ADRA1A | |
| SCHEMBL7983973 | 0.78 | HTR1B (0.49) | HTR1DHTR1BEGFRIGF1RFLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6172099-B1 | CARBAZOLE, DIBENZOFURAN, OR DIBENZOTHIOPHENE DERIVATIVES; DIETETICS, ANTIDIABETIC AGENTS; ANTILIPEMICS | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 2001-01-09 | — | — | US | disclosed |
| EP-0997458-A1 | NOVEL TRICYCLIC COMPOUNDS HAVING SATURATED RINGS AND MEDICINAL COMPOSITIONS CONTAINING THE SAME | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 2000-05-03 | — | — | EP | disclosed |