Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | FPR3 | P25089 | 1/20 | 0.44 |
| ▸ | FPR2 | P25090 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 11/20 | 0.41 |
| ▸ | STS | P08842 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8502163 | 0.73 | KDM4E (0.49) | KDM4EPKMFPR3FPR2TGFBR1 | |
| SCHEMBL21551436 | 0.70 | KDM4E (0.63) | KDM4EPKMFPR3FPR2STS | |
| SCHEMBL7983977 | 0.69 | KDM4E (0.50) | KDM4EPKMFPR3FPR2TGFBR1 | |
| SCHEMBL13947430 | 0.69 | KDM4E (0.80) | KDM4EPKMKMT2ATP53 | |
| SCHEMBL6148210 | 0.68 | KDM4E (0.71) | KDM4EPKMTGFBR1STSACKR3 | |
| SCHEMBL13812320 | 0.68 | KDM4E (0.60) | KDM4EPKMFPR3FPR2STS | |
| SCHEMBL31402457 | 0.68 | KDM4E (0.60) | KDM4EPKMFPR3FPR2STS | |
| SCHEMBL26131403 | 0.68 | KDM4E (1.00) | KDM4EPKMTGFBR1STSKMT2A | |
| SCHEMBL21551407 | 0.68 | KDM4E (0.63) | KDM4EPKMFPR3FPR2TGFBR1 | |
| SCHEMBL27604112 | 0.67 | KDM4E (0.54) | KDM4EPKMTGFBR1STS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235731-B1 | REDUCING BLOOD LIPIDS, SUGARS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-22 | — | — | US | disclosed |
| EP-0915888-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | Takeda Chemical Industries, Ltd. (JP) | 1999-05-19 | — | — | EP | disclosed |
| WO-1997040051-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-10-30 | — | — | WO | disclosed |