Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDR1 | Q08345 | 13/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14685916 | 0.87 | APEX1 (0.36) | APEX1ALDH1A1LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL781957 | 0.86 | DDR1 (0.36) | DDR1APEX1ALDH1A1LMNAMAPK1 | |
| SCHEMBL781955 | 0.86 | DDR1 (0.36) | DDR1APEX1ALDH1A1LMNAMAPK1 | |
| SCHEMBL29798955 | 0.86 | DDR1 (0.36) | DDR1APEX1ALDH1A1LMNAMAPK1 | |
| SCHEMBL15266530 | 0.84 | ALDH1A1 (0.35) | APEX1ALDH1A1LMNAMAPK1SMN1; SMN2 | |
| Succinic Acid SCHEMBL15267096 | 0.82 | ALDH1A1 (0.34) | ALDH1A1LMNAMAPK1SMN1; SMN2PKM | |
| SCHEMBL801411 | 0.79 | DDR1 (0.37) | DDR1ALDH1A1LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL782104 | 0.78 | DDR1 (0.35) | DDR1 | |
| SCHEMBL782106 | 0.78 | DDR1 (0.35) | DDR1 | |
| SCHEMBL29798823 | 0.78 | DDR1 (0.35) | DDR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616447-A1 | PYRAZINE DERIVATIVES AS ENAC BLOCKERS | Novartis AG (CH) | 2013-07-24 | — | — | EP | disclosed |
| WO-2012035158-A1 | PYRAZINE DERIVATIVES AS ENAC BLOCKERS | NOVARTIS AG (CH) | 2012-03-22 | — | — | WO | disclosed |