Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 8/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | MERTK | Q12866 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7980464 | 0.90 | PDE7A (0.52) | PDE7ARXFP1MAPTTP53 | |
| SCHEMBL3605146 | 0.90 | MERTK (0.46) | PDE7ARXFP1MAPTTP53MERTK | |
| SCHEMBL7987695 | 0.89 | MAPT (0.49) | PDE7ARXFP1MAPTTP53RAB9A | |
| SCHEMBL7971299 | 0.89 | MERTK (0.48) | PDE7ARXFP1MAPTTP53MERTK | |
| SCHEMBL7416384 | 0.88 | MAPT (0.51) | PDE7ARXFP1MAPTTP53CASP3 | |
| SCHEMBL7981717 | 0.88 | MERTK (0.44) | PDE7ARXFP1MAPTTP53MERTK | |
| SCHEMBL7987823 | 0.85 | NPC1 (0.49) | RXFP1MAPTTP53NPC1SMN1; SMN2 | |
| SCHEMBL7970614 | 0.83 | NAMPT (0.50) | NPC1SMN1; SMN2 | |
| SCHEMBL7987870 | 0.82 | HPGD (0.40) | PDE7ARXFP1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL7984203 | 0.80 | PDE4A (0.52) | RXFP1MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6262040-B1 | Indazole derivatives and their use as inhibitors of phosphodiesterase (PDE) type IV and the production of tumor necrosis factor (TNF) | PFIZER INC | 2001-07-17 | — | — | US | disclosed |