Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 11/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.49 |
| ▸ | KHK | P50053 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.43 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.43 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7987695 | 0.93 | MAPT (0.49) | PDE7ARXFP1KHKMAPTTP53 | |
| SCHEMBL7984065 | 0.90 | PDE7A (0.49) | PDE7ARXFP1MAPTTP53 | |
| SCHEMBL7416384 | 0.90 | MAPT (0.51) | PDE7ARXFP1MAPTTP53MEN1 | |
| SCHEMBL3176719 | 0.88 | TEAD1 (0.53) | PDE7AMAPTTEAD1TEAD4TEAD2 | |
| SCHEMBL7970490 | 0.87 | TEAD1 (0.52) | PDE7AMAPTTEAD1TEAD4TEAD2 | |
| SCHEMBL28743198 | 0.86 | NR1H4 (0.46) | MAPTTEAD1TEAD4TEAD2TP53 | |
| SCHEMBL7379307 | 0.86 | TEAD1 (0.53) | PDE7ATEAD1TEAD4TEAD2SLC22A12 | |
| SCHEMBL7970614 | 0.84 | NAMPT (0.50) | — | |
| SCHEMBL7970370 | 0.83 | PDE4A (0.44) | PDE7ARXFP1MAPTTEAD1TEAD4 | |
| SCHEMBL7987823 | 0.83 | NPC1 (0.49) | RXFP1MAPTTP53KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6262040-B1 | Indazole derivatives and their use as inhibitors of phosphodiesterase (PDE) type IV and the production of tumor necrosis factor (TNF) | PFIZER INC | 2001-07-17 | — | — | US | disclosed |
| CN-1234031-A | Indazole derivatives and their use as inhibitors of phosphodiesterase (PDE) type IV and the prodn. of tumor necrosis factor (TNF) | PFIZER (US) | 1999-11-03 | — | — | CN | disclosed |