Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.40 |
| ▸ | PDE7A | Q13946 | 3/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.36 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.36 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27500994 | 0.89 | TEAD1 (0.42) | PDK1PDK2PDK3PDK4OPRM1 | |
| SCHEMBL7970827 | 0.86 | TEAD1 (0.36) | PDE7ASLC22A12TEAD1TEAD4TEAD2 | |
| SCHEMBL28742871 | 0.85 | CNR2 (0.39) | PDE7ASLC22A12TEAD1TEAD4TEAD2 | |
| SCHEMBL7983565 | 0.81 | MEN1 (0.50) | PDE7AALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL3604069 | 0.80 | TEAD1 (0.43) | PDE7ASLC22A12TEAD1TEAD4TEAD2 | |
| SCHEMBL3176719 | 0.80 | TEAD1 (0.53) | PDE7ASLC22A12ALDH1A1TEAD1TEAD4 | |
| SCHEMBL3605146 | 0.79 | MERTK (0.46) | PDE7ASLC22A12ALDH1A1TEAD1TEAD4 | |
| SCHEMBL28742873 | 0.79 | CNR1 (0.40) | SLC22A12TEAD1TEAD4TEAD2CNR1 | |
| SCHEMBL3604745 | 0.79 | TEAD1 (0.42) | PDE7ASLC22A12TEAD1TEAD4TEAD2 | |
| SCHEMBL7377745 | 0.79 | SLC22A12 (0.42) | PDE7ASLC22A12TEAD1TEAD4TEAD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6262040-B1 | Indazole derivatives and their use as inhibitors of phosphodiesterase (PDE) type IV and the production of tumor necrosis factor (TNF) | PFIZER INC | 2001-07-17 | — | — | US | disclosed |