Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PDE7A | Q13946 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7983891 | 0.88 | HPGD (0.45) | MEN1KMT2AALDH1A1HPGDLMNA | |
| SCHEMBL8326204 | 0.84 | NPC1 (0.47) | MEN1KMT2AALDH1A1HPGDLMNA | |
| SCHEMBL7987870 | 0.84 | HPGD (0.40) | ALDH1A1HPGDLMNASMN1; SMN2PDE7A | |
| SCHEMBL27566563 | 0.84 | HPGD (0.47) | MEN1KMT2AALDH1A1HPGDLMNA | |
| SCHEMBL27517740 | 0.83 | HPGD (0.40) | MEN1KMT2AALDH1A1HPGDLMNA | |
| SCHEMBL7970370 | 0.82 | PDE4A (0.44) | ALDH1A1HPGDLMNASMN1; SMN2PDE7A | |
| SCHEMBL7980646 | 0.81 | NPY5R (0.50) | MEN1KMT2AALDH1A1HPGDLMNA | |
| SCHEMBL7984087 | 0.81 | PDK1 (0.40) | MEN1KMT2AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7984229 | 0.81 | PDE4A (0.46) | MEN1KMT2AALDH1A1HPGDLMNA | |
| SCHEMBL3605146 | 0.80 | MERTK (0.46) | MEN1KMT2AALDH1A1HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6262040-B1 | Indazole derivatives and their use as inhibitors of phosphodiesterase (PDE) type IV and the production of tumor necrosis factor (TNF) | PFIZER INC | 2001-07-17 | — | — | US | disclosed |