Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 6/20 | 0.40 |
| ▸ | RARB | P10826 | 3/20 | 0.39 |
| ▸ | RARG | P13631 | 3/20 | 0.39 |
| ▸ | RARA | P10276 | 2/20 | 0.39 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.39 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 2/20 | 0.36 |
| ▸ | MMP9 | P14780 | 2/20 | 0.36 |
| ▸ | MMP12 | P39900 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | FPR1 | P21462 | 1/20 | 0.36 |
| ▸ | FPR3 | P25089 | 1/20 | 0.36 |
| ▸ | GPR183 | P32249 | 1/20 | 0.36 |
| ▸ | APLNR | P35414 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7984342 | 0.77 | FFAR1 (0.40) | FFAR1RARBRARGRARACYP26A1 | |
| SCHEMBL5737003 | 0.71 | RARB (0.43) | FFAR1RARBRARGRARACYP26A1 | |
| SCHEMBL28239851 | 0.68 | SLC1A2 (0.41) | FFAR1LMNASLC1A2 | |
| SCHEMBL5735140 | 0.68 | NR4A1 (0.49) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL5737077 | 0.68 | RARB (0.45) | FFAR1RARBRARGRARACYP26A1 | |
| SCHEMBL7712760 | 0.68 | RARB (0.45) | FFAR1RARBRARGRARACYP26A1 | |
| SCHEMBL5737444 | 0.68 | KDM1A (0.47) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL402518 | 0.67 | RARB (0.62) | FFAR1RARBRARGRARACYP26A1 | |
| SCHEMBL6944938 | 0.66 | OPRL1 (0.58) | RARBRARGRARACYP26A1CYP3A4 | |
| Hydrochloric Acid SCHEMBL2707922 | 0.66 | RARB (0.60) | FFAR1RARBRARGRARACYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303785-B1 | SUBSTITUTED N-CYCLOPROPYLTETRAHYDROISOQUINOLINES | ALLERGAN SALES, INC. | 2001-10-16 | — | — | US | disclosed |