SCHEMBL7984527

SCHEMBL7984527

CC(O)C(=O)c1cc(Cl)ccc1OC(C)(C)c1nnc(-c2ccccc2C(F)(F)F)n1C

nearest known ligand 0.51

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 16/20 0.51
HSD11B2 P80365 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7982023 0.90 HSD11B1 (0.44) HSD11B1
SCHEMBL1417817 0.89 HSD11B1 (0.54) HSD11B1
SCHEMBL12671213 0.89 HSD11B1 (0.54) HSD11B1
Hydrochloric Acid SCHEMBL1418268 0.88 HSD11B1 (0.53) HSD11B1
SCHEMBL12671201 0.88 HSD11B1 (0.53) HSD11B1
SCHEMBL12671230 0.87 HSD11B1 (0.53) HSD11B1
SCHEMBL7985224 0.86 HSD11B1 (0.52) HSD11B1
SCHEMBL1417727 0.85 HSD11B1 (0.51) HSD11B1HSD11B2
SCHEMBL7979365 0.85 HSD11B1 (0.50) HSD11B1HSD11B2
SCHEMBL7988240 0.84 HSD11B1 (0.49) HSD11B1HSD11B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010001946-A1 TRIAZOLE DERIVATIVE OR SALT THEREOF アステラス製薬株式会社 (JP) 2010-01-07 WO disclosed