Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 12/20 | 0.61 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LYN | P07948 | 2/20 | 0.40 |
| ▸ | BTK | Q06187 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7980036 | 0.92 | LCK (0.54) | LCKPDPK1ALDH1A1KDM4ELMNA | |
| SCHEMBL7982990 | 0.84 | LCK (0.55) | LCKPDPK1POLBSRC | |
| SCHEMBL7983111 | 0.84 | LCK (0.58) | LCK | |
| SCHEMBL7983651 | 0.83 | LCK (0.59) | LCKPDPK1ALDH1A1KDM4ELMNA | |
| SCHEMBL7987022 | 0.80 | LCK (0.52) | LCKPDPK1POLBSRC | |
| SCHEMBL4041190 | 0.80 | LCK (0.51) | LCKPDPK1ALDH1A1KDM4ELMNA | |
| SCHEMBL7983212 | 0.79 | LCK (0.60) | LCKSRC | |
| SCHEMBL7981212 | 0.78 | LCK (0.48) | LCKPDPK1POLBSRC | |
| SCHEMBL7983395 | 0.77 | LCK (0.47) | LCKPDPK1POLBSRC | |
| SCHEMBL7983616 | 0.77 | LCK (0.51) | LCKALDH1A1KDM4ELMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | claimed |
| WO-1999009845-A1 | IMIDAZOQUINOXALINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-03-04 | — | — | WO | claimed |
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | disclosed |