Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 8/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.44 |
| ▸ | SRC | P12931 | 4/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.42 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7983395 | 0.94 | LCK (0.47) | LCKFGFR1SRCPDPK1FGFR2 | |
| SCHEMBL7981496 | 0.93 | LCK (0.47) | LCKFGFR1SRCPDPK1FGFR2 | |
| SCHEMBL7982990 | 0.93 | LCK (0.55) | LCKFGFR1SRCPDPK1FGFR2 | |
| SCHEMBL7981212 | 0.92 | LCK (0.48) | LCKSRCPDPK1POLB | |
| SCHEMBL7983212 | 0.83 | LCK (0.60) | LCKFGFR1SRCFGFR2FGFR4 | |
| SCHEMBL7983881 | 0.80 | FGFR1 (0.47) | LCKFGFR1SRCFGFR2FGFR4 | |
| SCHEMBL7984582 | 0.80 | LCK (0.61) | LCKSRCPDPK1POLB | |
| SCHEMBL7983651 | 0.78 | LCK (0.59) | LCKFGFR1SRCPDPK1FGFR2 | |
| SCHEMBL7980019 | 0.77 | LCK (0.52) | LCKFGFR1SRCFGFR2FGFR4 | |
| SCHEMBL4041190 | 0.75 | LCK (0.51) | LCKFGFR1SRCPDPK1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | claimed |
| WO-1999009845-A1 | IMIDAZOQUINOXALINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-03-04 | — | — | WO | claimed |
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | disclosed |