Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 19/20 | 0.66 |
| ▸ | PDE4B | Q07343 | 19/20 | 0.66 |
| ▸ | PDE4C | Q08493 | 19/20 | 0.66 |
| ▸ | PDE4D | Q08499 | 19/20 | 0.66 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7983133 | 0.83 | PDE4B (0.45) | PDE4APDE4BPDE4CPDE4DPDGFRB | |
| SCHEMBL6228197 | 0.82 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6585373 | 0.81 | PDE4A (0.63) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6586115 | 0.81 | PDE4A (0.64) | PDE4APDE4BPDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL6588638 | 0.80 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8344691 | 0.79 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL6590136 | 0.79 | PDE4D (0.98) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7450274 | 0.76 | PDE4D (0.66) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6592499 | 0.76 | PDE4D (0.77) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6233772 | 0.76 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329370-B1 | CARDIOVASCULAR DISORDERS AND TUMOR NECROSIS FACTOR (HEREINAFTER TNF.SUB..ALPHA.), A CYTOKINE WITH PRO-INFLAMMATORY ACTIVITY | ZAMBON GROUP S.P.A. (IT) | 2001-12-11 | — | — | US | disclosed |