Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 9/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.45 |
| ▸ | PDE4A | P27815 | 8/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7984800 | 0.83 | PDE4A (0.66) | PDE4BPDE4DPDE4APDE4CPDGFRB | |
| SCHEMBL6587456 | 0.73 | PDE4A (0.40) | PDE4BPDE4DPDE4APDE4CCYP17A1 | |
| SCHEMBL7984600 | 0.73 | PDE10A (0.52) | PDE4BPDE4DPDE4APDE4CPDE10A | |
| SCHEMBL6588404 | 0.70 | FLT1 (0.53) | PDE4BPDE4DPDE4APDE4CPDE10A | |
| SCHEMBL6586114 | 0.68 | PDE4D (0.51) | PDE4BPDE4DPDE4APDE4CPDGFRB | |
| SCHEMBL7451999 | 0.65 | PDE10A (0.51) | PDE4BPDE4DPDE4APDE4CPDE10A | |
| SCHEMBL6587711 | 0.64 | SHMT2 (0.54) | PDE4BPDE4DPDE4APDE4CCYP17A1 | |
| SCHEMBL6585981 | 0.64 | PDE4D (0.70) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6587932 | 0.63 | PDE4A (0.45) | PDE4BPDE4DPDE4APDE4CPDGFRB | |
| SCHEMBL7446753 | 0.63 | PDE4B (0.67) | PDE4BPDE4DPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329370-B1 | CARDIOVASCULAR DISORDERS AND TUMOR NECROSIS FACTOR (HEREINAFTER TNF.SUB..ALPHA.), A CYTOKINE WITH PRO-INFLAMMATORY ACTIVITY | ZAMBON GROUP S.P.A. (IT) | 2001-12-11 | — | — | US | disclosed |