Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.56 |
| ▸ | GAA | P10253 | 5/20 | 0.52 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | GLA | P06280 | 3/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18384865 | 0.88 | RIPK1 (0.55) | SMN1; SMN2GAAKEAP1NPC1RAB9A | |
| SCHEMBL8019525 | 0.82 | NPC1 (0.59) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL30123733 | 0.81 | SMN1; SMN2 (0.61) | SMN1; SMN2GAAKEAP1NPC1RAB9A | |
| SCHEMBL21588479 | 0.81 | SMN1; SMN2 (0.50) | SMN1; SMN2GAAKEAP1NPC1RAB9A | |
| SCHEMBL12297548 | 0.81 | SMN1; SMN2 (0.59) | SMN1; SMN2GAAKEAP1NPC1RAB9A | |
| SCHEMBL13994543 | 0.81 | SMN1; SMN2 (0.49) | SMN1; SMN2GAAKEAP1NPC1RAB9A | |
| SCHEMBL3748870 | 0.81 | SMN1; SMN2 (0.49) | SMN1; SMN2GAAKEAP1NPC1RAB9A | |
| SCHEMBL4500811 | 0.81 | NPC1 (0.50) | SMN1; SMN2GAANPC1RAB9AMEN1 | |
| SCHEMBL19141067 | 0.81 | DYRK1A (0.46) | SMN1; SMN2GAANPC1RAB9AMEN1 | |
| SCHEMBL27864412 | 0.81 | MAPT (0.64) | SMN1; SMN2GAANPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170253607-A1 | LONG-ACTING HIV PROTEASE INHIBITOR | SHIONOGI & CO., LTD. (JP) | 2017-09-07 | — | — | US | disclosed |
| WO-2001074771-A1 | PYRROLE-2,5-DIONE DERIVATIVES FOR THE TREATMENT OF DIABETES | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-10-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170253607-A1 | LONG-ACTING HIV PROTEASE INHIBITOR | CPN1, HAT1, PRSS1 | SMN1; SMN2 3538/4885GAA 1507/4885KEAP1 4173/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.