Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 16/20 | 0.52 |
| ▸ | AHR | P35869 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29924047 | 0.88 | AHR (0.54) | SMYD3AHREPHX2HDAC3 | |
| SCHEMBL28566338 | 0.88 | AHR (0.54) | SMYD3AHREPHX2HDAC3 | |
| SCHEMBL1557916 | 0.88 | SMYD3 (0.54) | SMYD3AHREPHX2HDAC3 | |
| SCHEMBL7971187 | 0.87 | CRBN (0.51) | SMYD3HDAC3 | |
| SCHEMBL1459962 | 0.85 | SMYD3 (0.52) | SMYD3AHREPHX2HDAC3 | |
| SCHEMBL5467073 | 0.85 | CRBN (0.46) | SMYD3 | |
| SCHEMBL28559882 | 0.82 | SMYD3 (0.51) | SMYD3AHREPHX2HDAC3 | |
| SCHEMBL29924234 | 0.82 | SMYD3 (0.51) | SMYD3AHREPHX2HDAC3 | |
| SCHEMBL7414824 | 0.82 | EPHX2 (0.56) | SMYD3AHREPHX2 | |
| SCHEMBL688076 | 0.80 | EPHX2 (0.56) | SMYD3AHREPHX2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6255322-B1 | NERVOUS SYSTEM DISORDERS; ALZHEIMER'S DISEASE | PFIZER INC. | 2001-07-03 | — | — | US | disclosed |
| EP-0554247-B1 | NEUROPROTECTIVE INDOLONE AND RELATED DERIVATIVES | PFIZER (US) | 2000-04-26 | — | — | EP | disclosed |
| US-5498610-A | Neuroprotective indolone and related derivatives | PFIZER INC. (US) | 1996-03-12 | — | — | US | disclosed |
| EP-0594729-A1 | 2-(4-HYDROXYPIPERIDINO)-1-ALKANOL DERIVATIVES AS ANTIISCHEMIC AGENTS | PFIZER INC. (US) | 1994-05-04 | — | — | EP | disclosed |
| US-5306723-A | Neuroprotective indolone and related derivatives | PFIZER INC. (US) | 1994-04-26 | — | — | US | disclosed |
| EP-0554247-A1 | NEUROPROTECTIVE INDOLONE AND RELATED DERIVATIVES | PFIZER INC. (US) | 1993-08-11 | — | — | EP | disclosed |
| WO-1993002052-A1 | 2-(4-HYDROXYPIPERIDINO)-1-ALKANOL DERIVATIVES AS ANTIISCHEMIC AGENTS | PFIZER INC. (US) | 1993-02-04 | — | — | WO | disclosed |
| WO-1991017156-A1 | NEUROPROTECTIVE INDOLONE AND RELATED DERIVATIVES | PFIZER INC (US) | 1991-11-14 | — | — | WO | disclosed |
| US-4678785-A | CARDIOTONICS, ANTICOAGULANTS | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1987-07-07 | — | — | US | disclosed |