Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 18/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1694230 | 0.81 | HRH4 (0.41) | HRH4HRH3KCNH2 | |
| SCHEMBL655118 | 0.77 | HRH4 (0.47) | HRH4HRH3KCNH2 | |
| SCHEMBL655109 | 0.74 | HRH4 (0.45) | HRH4HRH3KCNH2TLR8TLR7 | |
| SCHEMBL655384 | 0.72 | RAB9A (0.38) | TLR8TLR7MEN1ALDH1A1LMNA | |
| SCHEMBL793789 | 0.71 | HRH4 (0.46) | HRH4HRH3KCNH2 | |
| SCHEMBL605807 | 0.69 | HRH4 (0.47) | HRH4HRH3KCNH2TLR8TLR7 | |
| SCHEMBL15556511 | 0.68 | HRH4 (0.57) | HRH4 | |
| SCHEMBL655907 | 0.67 | HRH4 (0.57) | HRH4HRH3KCNH2 | |
| SCHEMBL602053 | 0.66 | HRH4 (0.44) | HRH4HRH3KCNH2ALDH1A1 | |
| SCHEMBL605900 | 0.65 | HRH4 (0.48) | HRH4HRH3KCNH2MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616077-A1 | ANTI-CANCER ACTIVITY OF NOVEL BICYCLIC HETEROCYCLES | Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) | 2013-07-24 | — | — | EP | disclosed |
| WO-2012035423-A1 | ANTI-CANCER ACTIVITY OF NOVEL BICYCLIC HETEROCYCLES | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2012-03-22 | — | — | WO | disclosed |