Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.59 |
| ▸ | FLT1 | P17948 | 3/20 | 0.59 |
| ▸ | FLT4 | P35916 | 3/20 | 0.59 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SLC2A2 | P11168 | 1/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7986691 | 0.94 | KDR (0.62) | KDRFLT1FLT4NFATC1GSK3B | |
| SCHEMBL7976570 | 0.92 | KDR (0.59) | KDRFLT1FLT4NFATC1GSK3B | |
| SCHEMBL7988266 | 0.91 | KDR (0.53) | KDRFLT1FLT4NFATC1GSK3B | |
| SCHEMBL7976928 | 0.91 | KDR (0.59) | KDRFLT1FLT4NFATC1GSK3B | |
| SCHEMBL7548749 | 0.91 | KDR (0.72) | KDRFLT1FLT4NFATC1GSK3B | |
| SCHEMBL7552346 | 0.90 | KDR (0.58) | KDRFLT1FLT4NFATC1GSK3B | |
| SCHEMBL7993928 | 0.88 | KDR (0.78) | KDRFLT1FLT4NFATC1GSK3B | |
| SCHEMBL7991008 | 0.85 | KDR (0.62) | KDRFLT1FLT4NFATC1GSK3B | |
| SCHEMBL7986681 | 0.85 | KDR (0.53) | KDRFLT1FLT4NFATC1GSK3B | |
| SCHEMBL7555564 | 0.84 | KDR (0.62) | KDRFLT1FLT4NFATC1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |