⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8717671 | 0.80 | — | — | |
| SCHEMBL1249258 | 0.79 | ALDH1A1 (0.53) | — | |
| SCHEMBL112149 | 0.79 | ALDH1A1 (0.53) | — | |
| SCHEMBL112148 | 0.79 | ALDH1A1 (0.53) | — | |
| SCHEMBL903490 | 0.79 | — | — | |
| SCHEMBL14763884 | 0.79 | ALDH1A1 (0.53) | — | |
| SCHEMBL18213891 | 0.79 | ALDH1A1 (0.53) | — | |
| SCHEMBL805601 | 0.79 | ALDH1A1 (0.53) | — | |
| SCHEMBL8645598 | 0.79 | ALDH1A1 (0.53) | — | |
| SCHEMBL28012631 | 0.79 | ALDH1A1 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291530-B1 | Aryl-substituted acrylamides with Leukotriene B4 (LTB-4) receptor antagonist activity | NOVARTIS AG (CH) | 2001-09-18 | — | — | US | disclosed |
| EP-0942903-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | Novartis AG (CH) | 1999-09-22 | — | — | EP | disclosed |
| WO-1998013347-A1 | ARYL-SUBSTITUTED ACRYLAMIDES WITH LEUKOTRIENE B4 (LTB-4) RECEPTOR ANTAGONIST ACTIVITY | NOVARTIS AG (CH) | 1998-04-02 | — | — | WO | disclosed |