SCHEMBL7987039

SCHEMBL7987039

O=C[C@H]1CN([C@H](CC2CC2)C(=O)O)C[C@@H]1c1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CCR5 P51681 20/20 0.52
CACNA1F O60840 1/20 0.48
CACNA1D Q01668 1/20 0.48
CACNA1S Q13698 1/20 0.48
CACNA1C Q13936 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7987043 1.00 CCR5 (0.52) CCR5CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL7495285 0.95 CCR5 (0.53) CCR5CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL7983281 0.95 CCR5 (0.53) CCR5CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL7661261 0.95 CCR5 (0.53) CCR5CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL7501869 0.95 CCR5 (0.53) CCR5CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL7661253 0.95 CCR5 (0.53) CCR5CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL7660606 0.88 CCR5 (0.54) CCR5
SCHEMBL7660608 0.88 CCR5 (0.54) CCR5
SCHEMBL7492200 0.88 CCR5 (0.54) CCR5
SCHEMBL7667301 0.84 CCR5 (0.37) CCR5CACNA1FCACNA1DCACNA1SCACNA1C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6265434-B1 ANTIINFLAMMATORY AGENTS MERCK & CO., INC. 2001-07-24 US disclosed