Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 1.00 |
| ▸ | NPC1 | O15118 | 6/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | HPGD | P15428 | 3/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.73 |
| ▸ | MEN1 | O00255 | 2/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.63 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7990425 | 0.99 | RAB9A (0.98) | RAB9ASMN1; SMN2NPC1LMNAHPGD | |
| SCHEMBL13305038 | 0.87 | RAB9A (0.77) | RAB9ASMN1; SMN2NPC1LMNAHPGD | |
| SCHEMBL7989436 | 0.86 | NPC1 (1.00) | RAB9ASMN1; SMN2NPC1LMNAHPGD | |
| Hydrochloric Acid SCHEMBL7976246 | 0.85 | NPC1 (0.97) | RAB9ASMN1; SMN2NPC1LMNAHPGD | |
| SCHEMBL7986579 | 0.80 | RAB9A (0.71) | RAB9ASMN1; SMN2NPC1LMNAHPGD | |
| SCHEMBL23657668 | 0.78 | NPC1 (0.69) | RAB9ASMN1; SMN2NPC1LMNAHPGD | |
| SCHEMBL13305064 | 0.77 | RAB9A (0.67) | RAB9ASMN1; SMN2NPC1LMNAHPGD | |
| SCHEMBL7021239 | 0.76 | LCK (0.67) | RAB9ASMN1; SMN2NPC1LMNAHPGD | |
| SCHEMBL28566503 | 0.76 | SMN1; SMN2 (0.62) | RAB9ASMN1; SMN2NPC1LMNAHPGD | |
| SCHEMBL7989417 | 0.76 | FGFR1 (1.00) | RAB9ASMN1; SMN2NPC1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218388-B1 | THERAPY OF PROTEIN TYROSINE KINASE MEDIATED CANCER, ATHEROSCLEROSIS, RESTENOSIS, AND PSORIASIS BY ADMINISTERING BENZIMIDAZOLE DERIVATIVE | WARNER-LAMBERT COMPANY | 2001-04-17 | — | — | US | disclosed |
| US-5990146-A | TREATING PROTEIN TYROSINE KINASE MEDIATED CANCER; ANTICARCINOGENIC AGENTS; ATHEROSCLEROSIS; RESTENOSIS; PSORIASIS; ANTIPROLIFERATIVE AGENTS | WARNER-LAMBERT COMPANY (US) | 1999-11-23 | — | — | US | disclosed |