Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.36 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.36 |
| ▸ | NSD2 | O96028 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL7987278 | 1.00 | KMT2A (0.41) | KMT2AMEN1PLA2G4BALDH1A1MAOB | |
| SCHEMBL4543075 | 0.94 | PRSS1 (0.38) | KMT2AMEN1ALDH1A1SMPD1 | |
| SCHEMBL4543078 | 0.94 | PRSS1 (0.38) | KMT2AMEN1ALDH1A1SMPD1 | |
| SCHEMBL7987286 | 0.86 | HIF1A (0.39) | KMT2AMEN1ALDH1A1SMPD1MAPT | |
| Oxalic Acid SCHEMBL4378004 | 0.86 | MAOB (0.47) | KMT2AMEN1PLA2G4BALDH1A1MAOB | |
| SCHEMBL4379687 | 0.85 | KMT2A (0.50) | KMT2AMEN1ALDH1A1MAOBSMN1; SMN2 | |
| SCHEMBL4543312 | 0.82 | KMT2A (0.49) | KMT2AMEN1ALDH1A1MAOBSMPD1 | |
| SCHEMBL4383633 | 0.81 | KMT2A (0.45) | KMT2APLA2G4BSMPD1 | |
| Oxalic Acid SCHEMBL4394339 | 0.81 | CNR1 (0.42) | KMT2AMEN1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL647793 | 0.81 | FURIN (0.43) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248765-B1 | ANTIINFLAMMATORY AGENTS; HYPOTENSIVE AGENTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL (FR) | 2001-06-19 | — | — | US | disclosed |