Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 9/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | PLG | P00747 | 1/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.36 |
| ▸ | C1S | P09871 | 1/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4543078 | 1.00 | PRSS1 (0.38) | PRSS1NPC1RAB9AKMT2AMEN1 | |
| Oxalic Acid SCHEMBL7987283 | 0.94 | KMT2A (0.41) | KMT2AMEN1ALDH1A1SMPD1 | |
| Oxalic Acid SCHEMBL7987278 | 0.94 | KMT2A (0.41) | KMT2AMEN1ALDH1A1SMPD1 | |
| SCHEMBL7987286 | 0.86 | HIF1A (0.39) | PRSS1KMT2AMEN1ALDH1A1SMPD1 | |
| SCHEMBL4379687 | 0.85 | KMT2A (0.50) | RAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL647792 | 0.85 | FURIN (0.43) | NPC1RAB9A | |
| SCHEMBL647793 | 0.85 | FURIN (0.43) | NPC1RAB9A | |
| SCHEMBL4543312 | 0.82 | KMT2A (0.49) | KMT2AMEN1ALDH1A1SMPD1 | |
| SCHEMBL4383633 | 0.81 | KMT2A (0.45) | KMT2ASMPD1 | |
| SCHEMBL4379352 | 0.80 | KMT2A (0.39) | PRSS1KMT2ASMPD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0760811-B1 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 MODULATORS | INST NAT SANTE RECH MED (FR) | 2009-11-18 | — | — | EP | disclosed |
| WO-1996029315-A2 | IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H3 (ANT)AGONISTS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1996-09-26 | — | — | WO | disclosed |