SCHEMBL7987569

SCHEMBL7987569

CC(C)(Oc1ccc(N)cc1)C(=O)NN

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.47
PPARA Q07869 9/20 0.46
CYP1A2 P05177 4/20 0.43
CYP3A4 P08684 4/20 0.43
CYP2C19 P33261 3/20 0.43
MAPT P10636 3/20 0.43
CYP2D6 P10635 2/20 0.43
CYP2C9 P11712 2/20 0.43
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43
HSD11B1 P28845 1/20 0.42
HSD11B2 P80365 1/20 0.42
PPARG P37231 2/20 0.41
POLB P06746 2/20 0.40
TDP1 Q9NUW8 2/20 0.40
NPC1 O15118 2/20 0.39
RAB9A P51151 2/20 0.39
HPGD P15428 1/20 0.39
MAPK1 P28482 1/20 0.39
SMN1; SMN2 Q16637 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7991793 0.86 CA1 (0.53) ALDH1A1PPARACYP1A2CYP3A4CYP2C19
SCHEMBL7983811 0.84 EPHX2 (0.50) ALDH1A1PPARACYP1A2CYP3A4CYP2C19
SCHEMBL1417538 0.84 ALDH1A1 (0.49) ALDH1A1PPARACYP1A2CYP3A4CYP2C19
SCHEMBL1417865 0.84 PPARA (0.65) ALDH1A1PPARACYP1A2CYP3A4CYP2C19
SCHEMBL1417819 0.81 ALDH1A1 (0.56) ALDH1A1PPARACYP1A2CYP3A4CYP2C19
SCHEMBL12670849 0.80 PPARA (0.52) ALDH1A1PPARACYP1A2CYP3A4CYP2C19
SCHEMBL1417805 0.80 PPARA (0.49) ALDH1A1PPARAMAPTMEN1KMT2A
SCHEMBL7998547 0.80 CYP3A4 (0.45) ALDH1A1PPARACYP3A4HSD11B1HSD11B2
SCHEMBL4000649 0.79 PPARA (0.47) ALDH1A1PPARACYP1A2CYP3A4CYP2C19
SCHEMBL787522 0.79 PPARA (0.67) ALDH1A1PPARACYP1A2CYP3A4CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2298747-A1 TRIAZOLE DERIVATIVE OR SALT THEREOF Astellas Pharma Inc. (JP) 2011-03-23 EP disclosed
WO-2010001946-A1 TRIAZOLE DERIVATIVE OR SALT THEREOF アステラス製薬株式会社 (JP) 2010-01-07 WO disclosed