Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 5/20 | 0.49 |
| ▸ | PTGER3 | P43115 | 5/20 | 0.49 |
| ▸ | PTGER2 | P43116 | 5/20 | 0.49 |
| ▸ | PTGER1 | P34995 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7987601 | 1.00 | PTGER4 (0.49) | PTGER4PTGER3PTGER2PTGER1GAA | |
| SCHEMBL6176435 | 0.80 | NPC1 (0.55) | ALDH1A1RAB9A | |
| SCHEMBL6176427 | 0.80 | NPC1 (0.55) | ALDH1A1RAB9A | |
| SCHEMBL7148105 | 0.79 | MAOB (0.50) | ALDH1A1LMNAMAPTPOLBRAB9A | |
| SCHEMBL7150103 | 0.79 | MAOB (0.50) | ALDH1A1LMNAMAPTPOLBRAB9A | |
| SCHEMBL8262659 | 0.79 | MAOB (0.50) | ALDH1A1LMNAMAPTPOLBRAB9A | |
| SCHEMBL10535624 | 0.78 | GAA (0.48) | PTGER4PTGER3PTGER2PTGER1GAA | |
| SCHEMBL10689694 | 0.78 | HTR1A (0.57) | PTGER4PTGER3PTGER2PTGER1GAA | |
| SCHEMBL7770104 | 0.78 | PTGER4 (0.70) | PTGER4PTGER3PTGER2PTGER1BRD4 | |
| SCHEMBL19651747 | 0.78 | PTGER4 (0.70) | PTGER4PTGER3PTGER2PTGER1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207686-B1 | FOR THERAPY OF HYPERTENSION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |
| EP-0792265-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-09-03 | — | — | EP | disclosed |
| WO-1996015109-A1 | ENDOTHELIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-23 | — | — | WO | disclosed |