Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 14/20 | 0.57 |
| ▸ | IGF1R | P08069 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7987798 | 1.00 | HPGD (0.57) | HPGDIGF1RGSK3BCISD1PIM1 | |
| SCHEMBL7998376 | 0.85 | HPGD (0.76) | HPGDCISD1PIM1PIM2PTPN1 | |
| SCHEMBL7998379 | 0.85 | HPGD (0.76) | HPGDCISD1PIM1PIM2PTPN1 | |
| SCHEMBL7987758 | 0.83 | KMT2A (0.47) | ALDH1A1LMNAGAAMAPT | |
| SCHEMBL7987934 | 0.82 | HPGD (0.63) | HPGDCISD1PIM1PIM2PTPN1 | |
| SCHEMBL7987937 | 0.82 | HPGD (0.63) | HPGDCISD1PIM1PIM2PTPN1 | |
| SCHEMBL8000465 | 0.80 | FFAR1 (0.47) | HPGDALDH1A1MAPTPTPN1 | |
| SCHEMBL7987720 | 0.78 | PRMT5 (0.53) | HPGDLMNAGAAMAPT | |
| SCHEMBL7996857 | 0.77 | HPGD (0.71) | HPGDCISD1PIM1PIM2PTPN1 | |
| SCHEMBL8003787 | 0.77 | HPGD (0.71) | HPGDCISD1PIM1PIM2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288096-B1 | ANTIDIABETIC AGENTS, HYPOTENSIVE AGENTS, AND ANTICHOLESTEROL AGENTS | ASTRAZENECA AB (SE) | 2001-09-11 | — | — | US | disclosed |
| EP-0991632-A1 | NEW THIAZOLIDINEDIONE, OXAZOLIDINEDIONE AND OXADIAZOLIDINEDIONE DERIVATIVES | Astra Aktiebolag (SE) | 2000-04-12 | — | — | EP | disclosed |
| WO-1998057941-A1 | NEW THIAZOLIDINEDIONE, OXAZOLIDINEDIONE AND OXADIAZOLIDINEDIONE DERIVATIVES | ASTRA AKTIEBOLAG (SE) | 1998-12-23 | — | — | WO | disclosed |