Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 11/20 | 0.65 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.59 |
| ▸ | PIM1 | P11309 | 2/20 | 0.58 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.55 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.52 |
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7987899 | 1.00 | HPGD (0.65) | HPGDCISD1PIM1PIM2HDAC4 | |
| SCHEMBL7987928 | 0.90 | HPGD (0.61) | HPGDCISD1PIM1PIM2HDAC4 | |
| SCHEMBL7987929 | 0.90 | HPGD (0.61) | HPGDCISD1PIM1PIM2HDAC4 | |
| SCHEMBL8000561 | 0.89 | HPGD (0.64) | HPGDCISD1PIM1PIM2HDAC4 | |
| SCHEMBL7987756 | 0.82 | HPGD (0.67) | HPGDCISD1PIM1PIM2PTPN1 | |
| SCHEMBL7987755 | 0.82 | HPGD (0.67) | HPGDCISD1PIM1PIM2PTPN1 | |
| SCHEMBL7987926 | 0.82 | HPGD (0.63) | HPGDCISD1PIM1PIM2GPR35 | |
| SCHEMBL7987925 | 0.82 | HPGD (0.63) | HPGDCISD1PIM1PIM2GPR35 | |
| SCHEMBL6381880 | 0.80 | HPGD (0.77) | HPGDCISD1PIM1PIM2PTPN1 | |
| SCHEMBL6381881 | 0.80 | HPGD (0.77) | HPGDCISD1PIM1PIM2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288096-B1 | ANTIDIABETIC AGENTS, HYPOTENSIVE AGENTS, AND ANTICHOLESTEROL AGENTS | ASTRAZENECA AB (SE) | 2001-09-11 | — | — | US | disclosed |
| EP-0991632-A1 | NEW THIAZOLIDINEDIONE, OXAZOLIDINEDIONE AND OXADIAZOLIDINEDIONE DERIVATIVES | Astra Aktiebolag (SE) | 2000-04-12 | — | — | EP | disclosed |
| WO-1998057941-A1 | NEW THIAZOLIDINEDIONE, OXAZOLIDINEDIONE AND OXADIAZOLIDINEDIONE DERIVATIVES | ASTRA AKTIEBOLAG (SE) | 1998-12-23 | — | — | WO | disclosed |