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SCHEMBL7987928

SCHEMBL7987928

CC(C)(C)OC(=O)Nc1ccc(CCOc2ccc(/C=C3\SC(=O)NC3=O)cc2)cc1

nearest known ligand 0.61

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ HPGD P15428 11/20 0.61
▸ CISD1 Q9NZ45 1/20 0.55
▸ PIM1 P11309 2/20 0.54
▸ PIM2 Q9P1W9 2/20 0.54
▸ GPR35 Q9HC97 1/20 0.50
▸ PTPN1 P18031 1/20 0.50
▸ HDAC4 P56524 3/20 0.49
▸ HDAC8 Q9BY41 2/20 0.49
▸ PPARG P37231 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7987929 1.00 HPGD (0.61) HPGDCISD1PIM1PIM2GPR35
SCHEMBL7987899 0.90 HPGD (0.65) HPGDCISD1PIM1PIM2GPR35
SCHEMBL7987903 0.90 HPGD (0.65) HPGDCISD1PIM1PIM2GPR35
SCHEMBL8000561 0.85 HPGD (0.64) HPGDCISD1PIM1PIM2GPR35
SCHEMBL7987926 0.82 HPGD (0.63) HPGDCISD1PIM1PIM2GPR35
SCHEMBL7987925 0.82 HPGD (0.63) HPGDCISD1PIM1PIM2GPR35
SCHEMBL30973657 0.82 PIM1 (0.60) HPGDCISD1PIM1PIM2GPR35
SCHEMBL8003930 0.81 PPARA (0.49) HPGDPPARG
SCHEMBL7987755 0.79 HPGD (0.67) HPGDCISD1PIM1PIM2PTPN1
SCHEMBL7987756 0.79 HPGD (0.67) HPGDCISD1PIM1PIM2PTPN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6288096-B1 ANTIDIABETIC AGENTS, HYPOTENSIVE AGENTS, AND ANTICHOLESTEROL AGENTS ASTRAZENECA AB (SE) 2001-09-11 — — US disclosed