Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 3/20 | 0.40 |
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | INSR | P06213 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.38 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6980882 | 1.00 | TLR8 (0.40) | TLR8PAK4KDRTP53LRRK2 | |
| SCHEMBL6978234 | 0.93 | TP53 (0.41) | TLR8PAK4TP53LIMK1LIMK2 | |
| SCHEMBL6978230 | 0.93 | TP53 (0.41) | TLR8PAK4TP53LIMK1LIMK2 | |
| SCHEMBL7226471 | 0.89 | LRRK2 (0.42) | TLR8PAK4KDRLRRK2EGFR | |
| SCHEMBL7226468 | 0.89 | LRRK2 (0.42) | TLR8PAK4KDRLRRK2EGFR | |
| SCHEMBL6975580 | 0.88 | HDAC1 (0.43) | TP53LIMK1LIMK2HDAC1HDAC6 | |
| SCHEMBL6975585 | 0.88 | HDAC1 (0.43) | TP53LIMK1LIMK2HDAC1HDAC6 | |
| SCHEMBL6985372 | 0.88 | HDAC1 (0.42) | LIMK1LIMK2NAMPTHDAC1HDAC6 | |
| SCHEMBL6985368 | 0.88 | HDAC1 (0.42) | LIMK1LIMK2NAMPTHDAC1HDAC6 | |
| SCHEMBL7985455 | 0.88 | JAK3 (0.44) | PAK4KDRLRRK2FLT3RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6169106-B1 | ANTITUMOUR AGENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-01-02 | — | — | US | disclosed |