Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | MMP14 | P50281 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11352030 | 0.88 | GAA (0.49) | KMT2AMEN1NPC1APOBEC3GKDM4E | |
| SCHEMBL22102774 | 0.86 | KMT2A (0.50) | KMT2AMEN1NPC1KDM4EMAPT | |
| SCHEMBL8885417 | 0.86 | MAPT (0.56) | KMT2AMEN1NPC1APOBEC3GKDM4E | |
| SCHEMBL4892335 | 0.85 | KMT2A (0.46) | KMT2AMEN1NPC1APOBEC3GKDM4E | |
| SCHEMBL4899234 | 0.83 | ALDH1A1 (0.51) | KMT2AMEN1NPC1APOBEC3GKDM4E | |
| SCHEMBL28501781 | 0.83 | EPHX1 (0.52) | KMT2AKDM4EMAPTGAAALDH1A1 | |
| SCHEMBL8883131 | 0.82 | POLB (0.47) | KMT2AMEN1NPC1APOBEC3GKDM4E | |
| SCHEMBL2817959 | 0.82 | GAA (0.63) | KMT2AMEN1NPC1KDM4EMAPT | |
| SCHEMBL5832931 | 0.81 | MAPT (0.66) | KMT2AMEN1NPC1KDM4EMAPT | |
| SCHEMBL8884143 | 0.81 | CYP3A4 (0.46) | KMT2AMEN1NPC1APOBEC3GMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218388-B1 | THERAPY OF PROTEIN TYROSINE KINASE MEDIATED CANCER, ATHEROSCLEROSIS, RESTENOSIS, AND PSORIASIS BY ADMINISTERING BENZIMIDAZOLE DERIVATIVE | WARNER-LAMBERT COMPANY | 2001-04-17 | — | — | US | disclosed |