Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.39 |
| ▸ | QPCT | Q16769 | 2/20 | 0.39 |
| ▸ | PRKCA | P17252 | 3/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7988030 | 0.91 | CDK4 (0.45) | GSK3BCCNE2CDK4CCND1CCNE1 | |
| SCHEMBL6948330 | 0.85 | CCNE2 (0.54) | GSK3BQPCTCCNE2CDK4CCND1 | |
| SCHEMBL7976559 | 0.83 | GSK3B (0.53) | GSK3BPRKCACCNE2CDK4CCND1 | |
| SCHEMBL7599053 | 0.82 | CCNE2 (0.51) | PRKCACCNE2CDK4CCND1CCNE1 | |
| SCHEMBL668748 | 0.80 | CCNE2 (0.57) | CCNE2CDK4CCND1CCNE1CDK2 | |
| SCHEMBL7988158 | 0.78 | GSK3B (0.51) | GSK3BPRKCAKDRCCNE2CDK4 | |
| SCHEMBL7990678 | 0.77 | GSK3B (0.59) | GSK3BPRKCAKDRCCNE2CDK4 | |
| SCHEMBL7059442 | 0.76 | GSK3B (0.57) | GSK3BPRKCACCNE2CDK4CCND1 | |
| SCHEMBL7976776 | 0.76 | CDK4 (0.67) | GSK3BPRKCACCNE2CDK4CCND1 | |
| SCHEMBL7508119 | 0.76 | CCNE2 (0.56) | CCNE2CDK4CCND1CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6281356-B1 | ANTICANRCER AGENTS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | claimed |
| US-6281356-B1 | ANTICANRCER AGENTS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | disclosed |