SCHEMBL7976776

SCHEMBL7976776

Cn1cc(C2=C(c3cn(C)c4cc(N5CCCC5)ccc34)C(=O)NC2=O)c2ccccc21

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK4 P11802 2/20 0.67
CCND1 P24385 2/20 0.67
CDK2 P24941 2/20 0.67
CCNE2 O96020 1/20 0.67
CCNE1 P24864 1/20 0.67
GSK3B P49841 4/20 0.60
GSK3A P49840 2/20 0.60
MEN1 O00255 1/20 0.60
RGS12 O14924 1/20 0.60
GMNN O75496 1/20 0.60
USP2 O75604 1/20 0.60
CCNB2 O95067 1/20 0.60
LMNA P02545 1/20 0.60
TP53 P04637 1/20 0.60
CYP1A2 P05177 1/20 0.60
CDK1 P06493 1/20 0.60
POLB P06746 1/20 0.60
CYP3A4 P08684 1/20 0.60
CYP2D6 P10635 1/20 0.60
MAPT P10636 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7987101 0.99 CDK4 (0.66) CDK4CCND1CDK2CCNE2CCNE1
SCHEMBL7987757 0.92 CCNE2 (0.66) CDK4CCND1CDK2CCNE2CCNE1
SCHEMBL7530443 0.90 GSK3B (0.72) CDK4CCND1CDK2CCNE2CCNE1
SCHEMBL7597574 0.88 CCNE2 (0.69) CDK4CCND1CDK2CCNE2CCNE1
SCHEMBL7529269 0.87 GSK3B (0.54) CDK4CCND1CDK2CCNE2CCNE1
SCHEMBL7524580 0.87 GSK3B (0.58) CDK4CCND1CDK2CCNE2CCNE1
SCHEMBL7990678 0.85 GSK3B (0.59) CDK4CCND1CDK2CCNE2CCNE1
SCHEMBL7525540 0.84 ALK (0.49) CDK4CCND1CDK2CCNE2CCNE1
SCHEMBL7523859 0.84 GSK3B (0.55) CDK4CCND1CDK2CCNE2CCNE1
SCHEMBL7988030 0.84 CDK4 (0.45) CDK4CCND1CDK2CCNE2CCNE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6281356-B1 ANTICANRCER AGENTS HOFFMANN-LA ROCHE INC. 2001-08-28 US claimed
US-6281356-B1 ANTICANRCER AGENTS HOFFMANN-LA ROCHE INC. 2001-08-28 US disclosed