SCHEMBL7988307

SCHEMBL7988307

CC(C)(C)OC(=O)N[C@@H](Cc1ccc(NS(=O)(=O)Cc2ccccc2)cc1)C(=O)O

nearest known ligand 0.60

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ACE P12821 1/20 0.60
ITGB3 P05106 2/20 0.54
ITGA2B P08514 2/20 0.54
CTSS P25774 3/20 0.54
CTSK P43235 2/20 0.54
CTSL P07711 1/20 0.54
CTSB P07858 1/20 0.54
PTPRB P23467 4/20 0.53
PPARA Q07869 2/20 0.53
PPARG P37231 1/20 0.53
APP P05067 1/20 0.52
PTPN1 P18031 2/20 0.52
ITGB1 P05556 1/20 0.51
ITGAV P06756 1/20 0.51
ITGB5 P18084 1/20 0.51
MAPK1 P28482 1/20 0.51
HDAC8 Q9BY41 1/20 0.50
AKT1 P31749 1/20 0.50
HPGD P15428 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7989052 0.86 ACE (0.58) ACEITGB3ITGA2BCTSSCTSK
SCHEMBL3820732 0.85 ACE (0.57) ACEITGB3ITGA2BCTSSCTSK
SCHEMBL27909397 0.85 ACE (0.79) ACEITGB3ITGA2BCTSSCTSK
SCHEMBL795685 0.85 ACE (0.79) ACEITGB3ITGA2BCTSSCTSK
SCHEMBL21473784 0.85 ACE (0.79) ACEITGB3ITGA2BCTSSCTSK
SCHEMBL67020 0.85 ACE (0.79) ACEITGB3ITGA2BCTSSCTSK
SCHEMBL606309 0.85 ACE (0.79) ACEITGB3ITGA2BCTSSCTSK
SCHEMBL66220 0.85 ACE (0.79) ACEITGB3ITGA2BCTSSCTSK
Water SCHEMBL15362012 0.83 ACE (0.77) ACEITGB3ITGA2BCTSSCTSK
SCHEMBL29707278 0.83 ACE (0.77) ACEITGB3ITGA2BCTSSCTSK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6265418-B1 ANTICOAGULANTS UBE INDUSTRIES, LTD. (JP) 2001-07-24 US disclosed
EP-1020467-A1 N-ACYLAMINO ACID AMIDE COMPOUNDS AND INTERMEDIATES FOR PREPARATION THEREOF UBE INDUSTRIES LIMITED (JP) 2000-07-19 EP disclosed