Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 15/20 | 0.55 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.42 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2548670 | 0.88 | METAP2 (0.71) | METAP2CHRNB4CHRNA3CHRNB1CHRNB2 | |
| SCHEMBL2546194 | 0.88 | METAP2 (0.69) | METAP2CHRNB4CHRNA3CHRNB1CHRNB2 | |
| SCHEMBL2546190 | 0.88 | METAP2 (0.69) | METAP2CHRNB4CHRNA3CHRNB1CHRNB2 | |
| SCHEMBL2548665 | 0.88 | METAP2 (0.71) | METAP2CHRNB4CHRNA3CHRNB1CHRNB2 | |
| SCHEMBL2541684 | 0.69 | METAP2 (0.51) | METAP2 | |
| SCHEMBL2541689 | 0.69 | METAP2 (0.51) | METAP2 | |
| SCHEMBL2547052 | 0.69 | METAP2 (1.00) | METAP2 | |
| SCHEMBL2547055 | 0.69 | METAP2 (1.00) | METAP2 | |
| SCHEMBL2547047 | 0.69 | METAP2 (0.57) | METAP2CHRNB4CHRNA3CHRNB1CHRNB2 | |
| SCHEMBL2547042 | 0.69 | METAP2 (0.57) | METAP2CHRNB4CHRNA3CHRNB1CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010003475-A2 | NOVEL PYRROLIDONE DERIVATIVES FOR USE AS METAP-2 INHIBITORS | MERCK PATENT GMBH (DE) | 2010-01-14 | — | — | WO | disclosed |