Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 11/20 | 0.57 |
| ▸ | CA2 | P00918 | 11/20 | 0.57 |
| ▸ | CA9 | Q16790 | 9/20 | 0.57 |
| ▸ | CA12 | O43570 | 8/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CA6 | P23280 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2365087 | 0.80 | CA1 (0.76) | CA1CA2CA9CA12POLB | |
| SCHEMBL22670400 | 0.77 | KMT2A (0.60) | CA1CA2CA9CA12POLB | |
| SCHEMBL11682423 | 0.76 | POLB (0.50) | CA1CA2CA9CA12POLB | |
| SCHEMBL9812745 | 0.76 | POLB (0.43) | CA1CA2CA9POLBMAPT | |
| SCHEMBL12438825 | 0.76 | POLB (0.50) | CA2CA9CA12POLBMAPT | |
| SCHEMBL5430471 | 0.76 | CA1 (0.51) | CA1CA2CA9CA12POLB | |
| SCHEMBL14572652 | 0.75 | GAA (0.70) | CA1CA2CA9CA12MAPT | |
| SCHEMBL1715679 | 0.74 | POLB (0.68) | CA1CA2CA9CA12POLB | |
| SCHEMBL8003872 | 0.73 | POLB (0.66) | CA1CA2CA9CA12POLB | |
| SCHEMBL3131292 | 0.73 | POLB (0.66) | CA1CA2CA9CA12POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271373-B1 | PYRIDINE DERIVATIVE FORMED BY REACTING A PYRAZINE DERIVATIVE WITH FECL3 AND ACETIC ACID | VIROPHARMA INCORPORATED | 2001-08-07 | — | — | US | disclosed |
| US-6180628-B1 | PYRIDAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH DERIVATIVES AND THEIR USE IN TREATING INFLUENZA INFECTION AND OTHER VIRAL DISEASES | VIROPHARMA INCORPORATED | 2001-01-30 | — | — | US | disclosed |
| EP-0920419-A4 | COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING INFLUENZA | VIROPHARMA INC (US) | 1999-10-06 | — | — | EP | disclosed |
| US-5935957-A | PYRIDAZINE DERIVATIVES | VIROPHARMA INCORPORATED (US) | 1999-08-10 | — | — | US | disclosed |
| EP-0920419-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING INFLUENZA | Viropharma Incorporated (US) | 1999-06-09 | — | — | EP | disclosed |
| US-5821243-A | 3,4,5-TRIOXO-2H,3H,4H,5H-PYRIDAZINES; TRANSCRIPTASE INHIBITORS; NONTOXIC | VIROPHARMA INCORPORATED (US) | 1998-10-13 | — | — | US | disclosed |
| WO-1998003487-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING INFLUENZA | VIROPHARMA INCORPORATED (US) | 1998-01-29 | — | — | WO | disclosed |