Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 known ✓ | O43570 | 2/20 | 0.39 |
| ▸ | CA1 known ✓ | P00915 | 2/20 | 0.39 |
| ▸ | CA2 known ✓ | P00918 | 2/20 | 0.39 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.39 |
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 4/20 | 0.66 |
| ▸ | GAA | P10253 | 7/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.40 |
| ▸ | LOX | P28300 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 6/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31197410 | 0.89 | POLB (0.50) | POLBGAAKDM4EMAPTNPC1 | |
| SCHEMBL1715679 | 0.87 | POLB (0.68) | POLBGAAKDM4EMAPTNPC1 | |
| SCHEMBL3131299 | 0.86 | POLB (0.50) | POLBGAAKDM4EMAPTNPC1 | |
| SCHEMBL8003873 | 0.86 | POLB (0.66) | POLBGAAKDM4EMAPTNPC1 | |
| SCHEMBL3131292 | 0.86 | POLB (0.66) | POLBGAAKDM4EMAPTNPC1 | |
| SCHEMBL12384188 | 0.80 | POLB (0.76) | POLBGAAKDM4EMAPTNPC1 | |
| SCHEMBL13597571 | 0.80 | POLB (0.76) | POLBGAAKDM4EMAPTNPC1 | |
| SCHEMBL14608274 | 0.80 | POLB (0.76) | POLBGAAKDM4EMAPTNPC1 | |
| SCHEMBL10654200 | 0.80 | POLB (0.58) | POLBGAAKDM4EMAPTNPC1 | |
| SCHEMBL3408946 | 0.80 | POLB (1.00) | POLBGAAKDM4EMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0614542-B1 | ARYLIDENE SENSITIZING DYES FOR TABULAR GRAINS | STERLING DIAGNOSTIC IMAGING (US) | 2000-01-19 | — | — | EP | disclosed |
| EP-0614542-A1 | ARYLIDENE SENSITIZING DYES FOR TABULAR GRAINS | Sterling Diagnostic Imaging, Inc. (US) | 1994-09-14 | — | — | EP | disclosed |
| US-5275928-A | Photographic element; hydrophilic colloid layer | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1994-01-04 | — | — | US | disclosed |
| WO-1993011458-A1 | ARYLIDENE SENSITIZING DYES FOR TABULAR GRAINS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1993-06-10 | — | — | WO | disclosed |