Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 3/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24455226 | 0.91 | TRPA1 (0.54) | TRPA1CHEK1MAPK1KDM4EMAPT | |
| SCHEMBL7028871 | 0.82 | CHEK1 (0.50) | TRPA1CHEK1MAPK1KDM4EMAPT | |
| SCHEMBL27227853 | 0.81 | CHEK1 (0.63) | TRPA1CHEK1MAPK1KDM4EMAPT | |
| SCHEMBL21901141 | 0.81 | CHEK1 (0.63) | TRPA1CHEK1MAPK1KDM4EMAPT | |
| SCHEMBL17120530 | 0.79 | TRPA1 (0.50) | TRPA1CHEK1MAPK1KDM4EMAPT | |
| SCHEMBL27445825 | 0.77 | TRPA1 (0.52) | TRPA1CHEK1MAPK1KDM4EMAPT | |
| SCHEMBL12311136 | 0.77 | AXL (0.51) | TRPA1CHEK1MAPK1KDM4EMAPT | |
| SCHEMBL17920385 | 0.77 | CHEK1 (0.48) | TRPA1CHEK1MAPK1KDM4EMAPT | |
| SCHEMBL7918116 | 0.77 | TRPA1 (0.49) | TRPA1CHEK1MAPK1KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL17442720 | 0.76 | CHEK1 (0.47) | TRPA1CHEK1MAPK1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6180627-B1 | INDOLE, INDAZOLE, BENZOTRIAZOLE AND BENZIMIDAZOLE DERIVATIVES | PFIZER INC. | 2001-01-30 | — | — | US | disclosed |