Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 6/20 | 0.39 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 5/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | BUB1 | O43683 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3797505 | 0.87 | GPR17 (0.40) | PTK2AURKATSHRNPC1LMNA | |
| SCHEMBL6695442 | 0.84 | GPR17 (0.40) | PTK2AURKATSHRNPC1LMNA | |
| SCHEMBL6412628 | 0.82 | PTK2 (0.35) | PTK2AURKATSHRNPC1LMNA | |
| SCHEMBL5413673 | 0.81 | KMT2A (0.50) | AURKANPC1LMNAGAASMN1; SMN2 | |
| SCHEMBL3802492 | 0.80 | GAA (0.46) | PTK2AURKATSHRNPC1LMNA | |
| SCHEMBL6407392 | 0.80 | ALDH1A1 (0.41) | PTK2AURKATSHRNPC1LMNA | |
| SCHEMBL6692185 | 0.79 | CDK4 (0.33) | PTK2TSHRNPC1LMNAGAA | |
| SCHEMBL6613602 | 0.78 | GAA (0.43) | NPC1LMNAGAASMN1; SMN2KDM4E | |
| SCHEMBL6614707 | 0.77 | PTK2 (0.35) | PTK2TSHRNPC1LMNAGAA | |
| SCHEMBL6617381 | 0.77 | KMT2A (0.41) | NPC1LMNAGAASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000008202-A9 | 3-METHYLIDENYL-2-INDOLINONE MODULATORS OF PROTEIN KINASE | SUGEN INC (US) | 2000-07-27 | — | — | WO | disclosed |
| WO-2000008202-A2 | 3-METHYLIDENYL-2-INDOLINONE MODULATORS OF PROTEIN KINASE | SUGEN, INC. (US) | 2000-02-17 | — | — | WO | disclosed |