Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 8/20 | 0.70 |
| ▸ | LMNA | P02545 | 3/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.70 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.70 |
| ▸ | ACHE | P22303 | 2/20 | 0.70 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.70 |
| ▸ | ESR1 | P03372 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 1/20 | 0.70 |
| ▸ | BLM | P54132 | 1/20 | 0.70 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.56 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.56 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | TNF | P01375 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5256903 | 1.00 | PDE4A (0.70) | PDE4ALMNACYP1A2NFKB1ACHE | |
| SCHEMBL8697424 | 1.00 | PDE4A (0.70) | PDE4ALMNACYP1A2NFKB1ACHE | |
| SCHEMBL8700216 | 0.96 | PDE4A (0.68) | PDE4ALMNACYP1A2NFKB1ACHE | |
| SCHEMBL8695792 | 0.96 | PDE4A (0.68) | PDE4ALMNACYP1A2NFKB1ACHE | |
| SCHEMBL8702218 | 0.96 | PDE4A (0.68) | PDE4ALMNACYP1A2NFKB1ACHE | |
| SCHEMBL11612265 | 0.95 | PDE4A (0.64) | PDE4ALMNACYP1A2NFKB1ACHE | |
| SCHEMBL4345194 | 0.95 | PDE4A (0.64) | PDE4ALMNACYP1A2NFKB1ACHE | |
| SCHEMBL11614003 | 0.94 | PDE4A (0.62) | PDE4ALMNACYP1A2NFKB1ACHE | |
| SCHEMBL11611955 | 0.94 | PDE4A (0.62) | PDE4ALMNACYP1A2NFKB1ACHE | |
| SCHEMBL10788514 | 0.94 | PDE4A (0.62) | PDE4ALMNACYP1A2NFKB1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0435153-B1 | R-(-)-1-(5-hydroxyhexyl)-3-methyl-7-propylxanthin, process for its preparation and medicines containing it | HOECHST AG (DE) | 1996-04-24 | — | — | EP | claimed |
| US-5478831-A | R-(-)1-(5-hydroxyhexyl)-3-methyl-7-propylxanthine, a process for its preparation and pharmaceuticals containing this compound | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-12-26 | — | — | US | claimed |
| US-5407815-A | Treating cerebral vascular disorders | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-04-18 | — | — | US | claimed |
| EP-0435153-A2 | R-(-)-1-(5-hydroxyhexyl)-3-methyl-7-propylxanthin, process for its preparation and medicines containing it | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-07-03 | — | — | EP | claimed |
| JP-4210688-A | — | — | None | — | — | JP | disclosed |
| WO-2000007541-A2 | USE OF XANTHINE DERIVATIVES FOR TREATING ERECTILE DISORDER | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-02-17 | — | — | WO | disclosed |
| US-5710272-A | INCREASING CEREBRAL BLOOD FLOW | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-01-20 | — | — | US | disclosed |
| EP-0435152-B1 | Process for the enantioselective preparation of (omega-1)-hydroxyalkylxanthines | HOECHST AG (DE) | 1996-11-13 | — | — | EP | disclosed |
| EP-0435153-B1 | R-(-)-1-(5-hydroxyhexyl)-3-methyl-7-propylxanthin, process for its preparation and medicines containing it | HOECHST AG (DE) | 1996-04-24 | — | — | EP | disclosed |
| EP-0435153-B1 | R-(-)-1-(5-hydroxyhexyl)-3-methyl-7-propylxanthin, process for its preparation and medicines containing it | HOECHST AG (DE) | 1996-04-24 | — | — | EP | disclosed |
| US-5478831-A | R-(-)1-(5-hydroxyhexyl)-3-methyl-7-propylxanthine, a process for its preparation and pharmaceuticals containing this compound | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-12-26 | — | — | US | disclosed |
| US-5478831-A | R-(-)1-(5-hydroxyhexyl)-3-methyl-7-propylxanthine, a process for its preparation and pharmaceuticals containing this compound | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-12-26 | — | — | US | disclosed |
| US-5407815-A | Treating cerebral vascular disorders | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-04-18 | — | — | US | disclosed |
| US-5310666-A | Vascular disorders | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-05-10 | — | — | US | disclosed |
| JP-H04210688-A | R-(-)-1-(5-HYDROXYHEXYL)-3-METHYL-7-PROPYLXANTHINE AND ITS PREPARATION | HOECHST AG | 1992-07-31 | — | — | JP | disclosed |
| EP-0435153-A3 | R-(-)-1-(5-HYDROXYHEXYL)-3-METHYL-7-PROPYLXANTHIN, PROCESS FOR ITS PREPARATION AND MEDICINES CONTAINING IT | — | 1992-05-13 | — | — | EP | disclosed |
| EP-0435152-A2 | Process for the enantioselective preparation of (omega-1)-hydroxyalkylxanthines | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-07-03 | — | — | EP | disclosed |
| EP-0435153-A2 | R-(-)-1-(5-hydroxyhexyl)-3-methyl-7-propylxanthin, process for its preparation and medicines containing it | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-07-03 | — | — | EP | disclosed |
| EP-0435153-A2 | R-(-)-1-(5-hydroxyhexyl)-3-methyl-7-propylxanthin, process for its preparation and medicines containing it | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-07-03 | — | — | EP | disclosed |
| EP-0435153-A2 | R-(-)-1-(5-hydroxyhexyl)-3-methyl-7-propylxanthin, process for its preparation and medicines containing it | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-07-03 | — | — | EP | disclosed |