Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 3/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.47 |
| ▸ | AKT2 | P31751 | 1/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.46 |
| ▸ | DHFR | P00374 | 1/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.44 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 2/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7989491 | 1.00 | NOX4 (0.51) | NOX4GSK3BPLK4PLK1LRRK2 | |
| SCHEMBL6388381 | 0.90 | NOX4 (0.60) | NOX4GSK3BPLK4PLK1LRRK2 | |
| SCHEMBL6388380 | 0.90 | NOX4 (0.60) | NOX4GSK3BPLK4PLK1LRRK2 | |
| SCHEMBL6390614 | 0.83 | NOX4 (0.60) | NOX4GSK3BLRRK2PDPK1AKT2 | |
| SCHEMBL6390621 | 0.83 | NOX4 (0.60) | NOX4GSK3BLRRK2PDPK1AKT2 | |
| SCHEMBL7717894 | 0.81 | GSK3B (0.52) | NOX4GSK3BLRRK2PDPK1AKT2 | |
| SCHEMBL14521220 | 0.79 | NTRK3 (0.49) | NOX4GSK3BPDPK1AKT2NTRK3 | |
| SCHEMBL6403898 | 0.79 | ERBB2 (0.58) | PLK4PLK1ERBB2DHFRALDH1A1 | |
| SCHEMBL6403896 | 0.79 | ERBB2 (0.58) | PLK4PLK1ERBB2DHFRALDH1A1 | |
| SCHEMBL6001502 | 0.76 | LRRK2 (0.72) | NOX4GSK3BPLK4PLK1LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000008202-A9 | 3-METHYLIDENYL-2-INDOLINONE MODULATORS OF PROTEIN KINASE | SUGEN INC (US) | 2000-07-27 | — | — | WO | disclosed |