Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 2/20 | 0.60 |
| ▸ | MPO | P05164 | 2/20 | 0.59 |
| ▸ | TPO | P07202 | 2/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | PDE4A | P27815 | 3/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | ACP1 | P24666 | 1/20 | 0.47 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9031047 | 0.87 | PNP (0.75) | PNPMPOTPOADORA3ADORA2B | |
| SCHEMBL8000339 | 0.77 | ADORA2A (0.54) | MPOTPOADORA3ADORA2BPDE4A | |
| SCHEMBL7682667 | 0.77 | PNP (0.60) | PNPMPOTPOADORA3ADORA2B | |
| SCHEMBL9032111 | 0.75 | PNP (1.00) | PNPMPOTPOADORA3ADORA2B | |
| SCHEMBL8002258 | 0.75 | PDE4A (0.56) | ADORA3ADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL1460860 | 0.74 | MPO (1.00) | PNPMPOTPOADORA3ADORA2B | |
| SCHEMBL2286250 | 0.74 | MPO (0.77) | PNPMPOTPOADORA3ADORA2B | |
| SCHEMBL1460888 | 0.74 | ADORA2A (0.55) | MPOTPOADORA3ADORA2BKMT2A | |
| SCHEMBL1461128 | 0.73 | PNP (0.62) | PNPMPOTPOADORA3ADORA2B | |
| SCHEMBL1388113 | 0.73 | APOBEC3G (0.43) | PNPKMT2AKDM4EPOLBAPOBEC3G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6294541-B1 | ENZYME INHIBITORS USING PURINE COMPOUNDS AS ANTIHISTAMINES | EURO-CELTIQUE S.A. (LU) | 2001-09-25 | — | — | US | claimed |
| EP-0916673-A1 | 6-Amino purine derivatives having PDE-IV inhibition activity | Euroceltique S.A. (LU) | 1999-05-19 | — | — | EP | disclosed |
| EP-0916672-A1 | 6-Amino purine derivatives having PDE-IV inhibition activity and intermediates | Euroceltique S.A. (LU) | 1999-05-19 | — | — | EP | disclosed |